I've never tried it on Vista. But Kheops has a webpage on getting their games to work on Vista
http://www.kheops-studio.com/support/14so apparently they think it will work once you disable UAC.
You should probably also try installing it to My Documents instead of C:\Program Files.
It is listed as working on Windows 7 in the Windows 7 and Games thread, so it should work on modern computers.